Arcangela Iuso is a senior scientist at the Helmholtz Zentrum München and the scientific coordinator of the international biobank for Neurodegeneration with Brain Iron Accumulation (NBIA) at the Technical University of Munich, Germany. She conducts basic and pre-clinical research on mitochondrial disorders, with a focus on NBIA and metabolically related disorders, such as those resulting from PPCS and SLC25A42 deficiency. She is interested in understanding the function of poorly characterized proteins to explore rational therapeutic strategies. To this aim, she uses a range of model systems, including primary patient samples, stem cell models, and genetically modified fruit flies and mice.